Esketamine alleviates LPS-induced depression-like behavior by activating Nrf2-mediated anti-inflammatory response in adolescent mice

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

Eri Kobayashi, Takafumi Suzuki, Ryo Funayama et al. · Nature Communications · 2016 · 1.8K citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

Jason C. O’Connor, Mark A. Lawson, Caroline André et al. · Molecular Psychiatry · 2008 · 1.3K citations · Full text

Medicine, Neuroscience, Pharmacology +14

Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study

Vanina Popova, Ella Daly, Madhukar H. Trivedi et al. · American Journal of Psychiatry · 2019 · 872 citations · Full text

Pharmacy, Pharmacotherapy, Psychiatry +17

Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression

Ella Daly, Jaskaran Singh, Maggie Fedgchin et al. · JAMA Psychiatry · 2017 · 705 citations · Full text

Pharmacy, Pharmacotherapy, Psychiatry +16

Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1)

Maggie Fedgchin, Madhukar H. Trivedi, Ella Daly et al. · The International Journal of Neuropsychopharmacology · 2019 · 590 citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +17