Concepedia

K90 lactylation orchestrates YAP nuclear sequestration by impairing binding with exportin CRM1 and enhances HCC malignancy

Li Wang, Tanlun Zeng, Yichuan Wang, Guang Wang, Weichen Yu, Jian Zhang, Yihai Shi, Jixi Li, Jin Ding

Cancer Letters · 2024 · 12 citations · 11 references

DOI

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References

11

Metabolic regulation of gene expression by histone lactylation

Di Zhang, Zhanyun Tang, He Huang et al. · Nature · 2019 · 3.9K citations · Full text

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Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals

Jixin Dong, Georg Feldmann, Jianbin Huang et al. · Cell · 2007 · 2.4K citations · Full text

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Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma

Zijian Yang, Cong Yan, Jiaqiang Ma et al. · Nature Metabolism · 2023 · 545 citations

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Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis

Zhi Zong, Feng Xie, Shuai Wang et al. · Cell · 2024 · 496 citations

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YAP/TAZ and ATF4 drive resistance to Sorafenib in hepatocellular carcinoma by preventing ferroptosis

Ruize Gao, Ravi Kiran Reddy Kalathur, Mairene Coto‐Llerena et al. · EMBO Molecular Medicine · 2021 · 493 citations · Full text

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