Strategic delivery of rapamycin and ranibizumab with intravitreal hydrogel depot disrupts multipathway-driven angiogenesis loop for boosted wAMD therapy

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

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Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration

Kai Kaarniranta, Debasish Sinha, Janusz Błasiak et al. · Autophagy · 2013 · 327 citations · Full text

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BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1α, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin

Matthias Mayerhofer, Peter Valent, Wolfgang R. Sperr et al. · Blood · 2002 · 275 citations

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Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration

Szabolcs Felszeghy, Johanna Viiri, Jussi J. Paterno et al. · Redox Biology · 2018 · 161 citations · Full text

Life Sciences, Molecular Biology, Ophthalmology +17

Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells

Tim U. Krohne, Nina Stratmann, Jürgen Kopitz et al. · Experimental Eye Research · 2010 · 157 citations

Life Sciences, Cell Biology, Ophthalmology +14