Cell Death and Disease · 2024 · 16 citations · 22 references
Life SciencesCell BiologyMolecular BiologyCell SignalingInflammationMolecular Cell BiologyCell DeathDeath ReceptorsImmunogenic Cell DeathInflammatory SignalingCell Death In InflammationCell Death RegulatorsCell Death Signaling PathwaysIntrinsic Cell Death PathwayMembrane Rupture MechanicsProgrammed Cell Death RegulationTransmembrane DomainsTransmembrane Protein Topology
NINJ1, a critical transmembrane protein in inflammation, governs diverse biological processes. Recent breakthroughs revealed NINJ1's structural basis for plasma membrane rupture, which is directly linked to lytic cell death. This discussion explores NINJ1's functions, focusing on its pivotal role in lytic cell death regulation and the latest advancements in targeted therapeutic interventions.
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FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
Jun Hu, Xing Liu, Shiyu Xia et al. · Nature Immunology · 2020 · 1.1K citations · Full text
NINJ1 mediates plasma membrane rupture during lytic cell death
Nobuhiko Kayagaki, Opher S. Kornfeld, Bettina L. Lee et al. · Nature · 2021 · 808 citations
Succination inactivates gasdermin D and blocks pyroptosis
Fiachra Humphries, Liraz Shmuel-Galia, Natália Ketelut-Carneiro et al. · Science · 2020 · 655 citations · Full text
Gasdermin D pore structure reveals preferential release of mature interleukin-1
Shiyu Xia, Zhibin Zhang, Venkat Giri Magupalli et al. · Nature · 2021 · 610 citations · Full text