<i>APOL1</i> Bi- and Monoallelic Variants and Chronic Kidney Disease in West Africans

Abstract

BACKGROUND: variants with CKD in West Africans, a major group in the Black population. METHODS: risk alleles) by fitting logistic-regression models that controlled for covariates, including clinical site, age, and sex. RESULTS: variants with CKD or focal segmental glomerulosclerosis. CONCLUSIONS: variants were associated with 25% higher odds of CKD and 84% higher odds of focal segmental glomerulosclerosis. (Funded by the National Human Genome Research Institute and others.).