Concepedia

Targeting CD93 on monocytes revitalizes antitumor immunity by enhancing the function and infiltration of CD8<sup>+</sup> T cells

Da Jiang, Ai-Qi Huang, Bai-Xi Zhu, Jiangling Gong, Yong-Hao Ruan, Xing-Chen Liu, Limin Zheng, Yan Wu

Journal for ImmunoTherapy of Cancer · 2024 · 10 citations · 25 references

DOIFull text

Open access

Abstract

This study identified an important mechanism contributing to the activation and limited infiltration of CD8<sup>+</sup> T cells in solid tumors, and CD93<sup>+</sup> monocytes might represent a plausible immunotherapeutic target for the treatment of HCC.

References

25

TIMER2.0 for analysis of tumor-infiltrating immune cells

Taiwen Li, Jingxin Fu, Zexian Zeng et al. · Nucleic Acids Research · 2020 · 5.5K citations · Full text

Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma

Adrian Ally, Miruna Balasundaram, Rebecca Carlsen et al. · Cell · 2017 · 2.5K citations · Full text

Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity

Chia‐Wei Li, Seung-Oe Lim, Weiya Xia et al. · Nature Communications · 2016 · 1.1K citations · Full text

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1

Dong‐Ming Kuang, Qiyi Zhao, Peng Chen et al. · The Journal of Experimental Medicine · 2009 · 894 citations · Full text

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TISCH2: expanded datasets and new tools for single-cell transcriptome analyses of the tumor microenvironment

Ya Han, Yuting Wang, Xin Dong et al. · Nucleic Acids Research · 2022 · 553 citations · Full text