International Journal of Biological Sciences · 2024 · 25 citations · 1 references
Life SciencesMolecular BiologyOncologyCell SignalingInflammationMolecular OncologyColorectal CancerMetabolic Reprogramming In CancerOxidative Stress In InflammationPeroxiredoxin BiologyReactive Oxygen SpeciesRedox SignalingNrf2 Pathway ActivationNrf2 Signaling PathwayNrf2-mediated Cytoprotective SignalingNrf2-mediated ResponsesOxidative Stress In CancerOxidative Stress Signaling DisruptionRedox Metabolism In CancerRedox Signaling In Inflammation
. Collectively, these results provide a novel insight into the molecular chaperone activity of PRDX1 in promoting CRC progression through suppression of CUL3-mediated NRF2 degradation, suggesting PRDX1 Cys83 is a potential drug target in inhibiting CRC.
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Expression of peroxiredoxin 1 and 4 promotes human lung cancer malignancy.
Hong Jiang, Lisha Wu, Murli Mishra et al. · PubMed · 2014 · 59 citations · Full text