Circulating extracellular vesicle-carried PTP1B and PP2A phosphatases as regulators of insulin resistance

Abstract

These data demonstrate that inhibition of phosphatases carried by EVs from IR participants rescues insulin signalling in adipocytes and hepatocytes and point towards PTP1B and PP2A carried by IR EVs as being novel potential therapeutic targets against insulin resistance in adipose tissue and liver and the development of obesity.