Revealing the association between East Asian oral microbiome and colorectal cancer through Mendelian randomization and multi-omics analysis

Abstract

This study establishes the critical role of the oral microbiome in colorectal cancer development, identifying specific microbial taxa linked to CRC risk. Single-cell RNA sequencing and drug prediction analyses further elucidate key pathways and potential therapeutics, providing novel insights and personalized treatment strategies for CRC.