Concepedia

High‐concentration hydrogen inhalation mitigates sepsis‐associated encephalopathy in mice by improving mitochondrial dynamics

Yan Cui, Shuqi Meng, Nannan Zhang, Jingya Liu, Lina Zheng, Wanjie Ma, Yu Song, Zhiwei Wang, Yuehao Shen, Jianfeng Liu,

CNS Neuroscience & Therapeutics · 2024 · 10 citations · 21 references

DOIFull text

Open access

Abstract

Inhalation of high concentration (67%) of H<sub>2</sub> in septic mice improved the survival rate and reduced neuronal injury. Its mechanism might be mediated by enhancing mitochondrial biogenesis and mitochondrial dynamics.

References

21

Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy

Bereketeab Haileselassie, Amit U. Joshi, Paras S. Minhas et al. · Journal of Neuroinflammation · 2020 · 190 citations · Full text

Effect of early mobilisation on long-term cognitive impairment in critical illness in the USA: a randomised controlled trial

Bhakti K. Patel, K.S. Wolfe, Shruti Patel et al. · The Lancet Respiratory Medicine · 2023 · 167 citations · Full text

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Evidence of oxidative stress and mitochondrial respiratory chain dysfunction in an in vitro model of sepsis-induced kidney injury

Caroline Quoilin, Ange Mouithys‐Mickalad, Sandrine Lécart et al. · Biochimica et Biophysica Acta (BBA) - Bioenergetics · 2014 · 153 citations

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PI3K/Akt pathway-mediated HO-1 induction regulates mitochondrial quality control and attenuates endotoxin-induced acute lung injury

Jia Shi, Jianbo Yu, Yuan Zhang et al. · Laboratory Investigation · 2019 · 152 citations · Full text

Sepsis Guidelines

Angela Chen, Steven Q. Simpson, Daniel J. Pallin · New England Journal of Medicine · 2019 · 73 citations

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