Concepedia

Dual role of exosomal circCMTM3 derived from GSCs in impeding degradation and promoting phosphorylation of STAT5A to facilitate vasculogenic mimicry formation in glioblastoma

Chengbin Wang, Yingliang Liu, Zhenxing Zuo, Daming Cui, Yuzhen Xu, Li Li, Yangfu Jiang

Theranostics · 2024 · 16 citations · 28 references

DOIFull text

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Concepts

Abstract

Exosomal circCMTM3 possessing growth factor-mimetic property activates the JAK2/STAT5A pathway via non-canonical manner, and promotes VM formation in GBM. The molecular communications between GSCs and DGCs offers a therapeutic strategy for targeting the neovascularization of GBM.

References

28

EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3

Ziwen Pan, Rongrong Zhao, Boyan Li et al. · Molecular Cancer · 2022 · 326 citations · Full text

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Exosome-derived circCCAR1 promotes CD8 + T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma

Zongqiang Hu, Gang Chen, Yingpeng Zhao et al. · Molecular Cancer · 2023 · 315 citations · Full text

, , +17

Oncogenic Splicing Factor SRSF1 Is a Critical Transcriptional Target of MYC

Shipra Das, Olga Anczuków, Martin Akerman et al. · Cell Reports · 2012 · 202 citations · Full text

, , +17

Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma

Xiao Zhang, Yunhua Xu, Lifang Ma et al. · Cancer Communications · 2022 · 194 citations · Full text

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A Splicing-Independent Function of SF2/ASF in MicroRNA Processing

Han Wu, Shuying Sun, Kang Tu et al. · Molecular Cell · 2010 · 191 citations · Full text

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