Concepedia

Caffeic acid ameliorates metabolic dysfunction-associated steatotic liver disease via alleviating oxidative damage and lipid accumulation in hepatocytes through activating Nrf2 via targeting Keap1

Jinyu Zhang, Hao Ouyang, Xin-Nan Gu, Shiyuan Dong, Bin Lü, Zhenlin Huang, Jian Li, Lili Ji

Free Radical Biology and Medicine · 2024 · 42 citations · 17 references

References

17

Design and validation of a histological scoring system for nonalcoholic fatty liver disease†

David E. Kleiner, Elizabeth M. Brunt, Mark L. Van Natta et al. · Hepatology · 2005 · 10.7K citations

Medicine, Pathology, Gastroenterology +16

Identification of a novel FGF, FGF-21, preferentially expressed in the liver

Tetsuya Nishimura, Yuhki Nakatake, Morichika Konishi et al. · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · 2000 · 838 citations

Life Sciences, Developmental Biology, Molecular Biology +11

Randomized, Controlled Trial of the FGF21 Analogue Pegozafermin in NASH

Rohit Loomba, Arun J. Sanyal, Kris V. Kowdley et al. · New England Journal of Medicine · 2023 · 442 citations · Full text

Pharmacy, Pharmacology, Pharmacotherapy +9

Safety and efficacy of once-weekly efruxifermin versus placebo in non-alcoholic steatohepatitis (HARMONY): a multicentre, randomised, double-blind, placebo-controlled, phase 2b trial

Stephen A. Harrison, Juan P. Frías, Guy Neff et al. · The Lancet. Gastroenterology & hepatology · 2023 · 235 citations

Medicine, Pharmacology, Pharmacotherapy +8

Caffeic acid prevents acetaminophen-induced liver injury by activating the Keap1-Nrf2 antioxidative defense system

Chun Pang, Zhiyong Zheng, Liang Shi et al. · Free Radical Biology and Medicine · 2015 · 211 citations

Veterinary Medicine, Pharmacology, Inflammation +10