Study on the underlying mechanism of Huachansu Capsule induced cardiotoxicity of normal rat by integrating transcriptomics, metabolomics and network toxicology

Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy

Qing-Bo Lu, Yi Ding, Yao Liu et al. · Journal of Advanced Research · 2022 · 149 citations · Full text

Life Sciences, Cardiology, Endocrinology +17

Combining network pharmacology, RNA-seq, and metabolomics strategies to reveal the mechanism of Cimicifugae Rhizoma - Smilax glabra Roxb herb pair for the treatment of psoriasis

XueQing Hu, Cong Qi, Fang Feng et al. · Phytomedicine · 2022 · 71 citations

Life Sciences, Molecular Medicine, Pharmacology +16

A bioinformatics and transcriptomics based investigation reveals an inhibitory role of Huanglian-Renshen-Decoction on hepatic glucose production of T2DM mice via PI3K/Akt/FoxO1 signaling pathway

Fan Wu, Qingqing Shao, Qingsong Xia et al. · Phytomedicine · 2021 · 54 citations

Life Sciences, Bioinformatics, Molecular Biology +17

Cardiac contraction and relaxation are regulated by distinct subcellular cAMP pools

Ting‐Yu Lin, Hao Zhang, Emily B. Wilson et al. · Nature Chemical Biology · 2023 · 52 citations · Full text

Life Sciences, Cell Biology, Physiology +17

Integrated network toxicology, molecular docking, and in vivo experiments to elucidate molecular mechanism of aflatoxin B1 hepatotoxicity

Bingjie Ge, Kexin Yan, Rui Sang et al. · Ecotoxicology and Environmental Safety · 2024 · 52 citations · Full text

Pharmacy, Toxicology, Apoptosis +16