Concepedia

Safety, pharmacokinetics, and pharmacodynamics of LBP-EC01, a CRISPR-Cas3-enhanced bacteriophage cocktail, in uncomplicated urinary tract infections due to Escherichia coli (ELIMINATE): the randomised, open-label, first part of a two-part phase 2 trial

Paul Kim, Ana M. Sánchez, Taylor J.R. Penke, Hannah H. Tuson, J. Kime, Robert W. McKee, William L. Slone, Nicholas R. Conley, Lana J. McMillan, Cameron J. Prybol,

The Lancet Infectious Diseases · 2024 · 83 citations · 15 references

References

15

Lysis from without

Stephen T. Abedon · Bacteriophage · 2011 · 404 citations · Full text

Life Sciences, Microbiology, Bacteriology +9

Phage-Antibiotic Synergy Is Driven by a Unique Combination of Antibacterial Mechanism of Action and Stoichiometry

Carmen Gu Liu, Sabrina I. Green, Lorna Min et al. · mBio · 2020 · 364 citations · Full text

Life Sciences, Microbiology, Pharmacology +17

Disease burden and long-term trends of urinary tract infections: A worldwide report

Xiaorong Yang, Hui Chen, Yue Zheng et al. · Frontiers in Public Health · 2022 · 348 citations · Full text

Public Health, Infectious Diseases, Urology +14

Lessons Learned From the First 10 Consecutive Cases of Intravenous Bacteriophage Therapy to Treat Multidrug-Resistant Bacterial Infections at a Single Center in the United States

Saima Aslam, Elizabeth Lampley, Darcy Wooten et al. · Open Forum Infectious Diseases · 2020 · 335 citations · Full text

Pharmacy, Infectious Diseases, Pharmacotherapy +15

Intravesical bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: a randomised, placebo-controlled, double-blind clinical trial

Lorenz Leitner, Aleksandre Ujmajuridze, Marina Goderdzishvili et al. · The Lancet Infectious Diseases · 2020 · 312 citations

Medicine, Surgery, Urology +17