Deletion of complement C4 and steroid 21-hydroxylase genes in the HLA class III region.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

E.M. Southern · Journal of Molecular Biology · 1975 · 32.8K citations

Chromatin, Dna Sequencing, Dna +15

A rapid alkaline extraction procedure for screening recombinant plasmid DNA

H.C. Birnboim, Janine Doly · Nucleic Acids Research · 1979 · 14.8K citations · Full text

Genetics, Bacteriology, Bacteriophage +18

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

Peter Rigby, Marianne Dieckmann, Carl Rhodes et al. · Journal of Molecular Biology · 1977 · 11.7K citations

Nucleic Acid Chemistry, High Specific Activity, Biochemistry +8

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

Geoffrey M. Wahl, Michael Stern, George R. Stark · Proceedings of the National Academy of Sciences · 1979 · 3.4K citations · Full text

Engineering, Agarose Gels, Dna Analysis +17

Polymorphic DNA region adjacent to the 5' end of the human insulin gene.

G I Bell, J H Karam, W J Rutter · Proceedings of the National Academy of Sciences · 1981 · 900 citations

Chromatin, Genetic Analysis, Genetic Determinant +15