Design and lyophilization of mRNA-encapsulating lipid nanoparticles

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

Akin Akinc, Martin A. Maier, Muthiah Manoharan et al. · Nature Nanotechnology · 2019 · 1.6K citations · Full text

Pharmacy, Molecular Pharmaceutics, Pharmacology +16

A Thermostable mRNA Vaccine against COVID-19

Na-Na Zhang, Xiao-Feng Li, Yong‐Qiang Deng et al. · Cell · 2020 · 690 citations · Full text

Veterinary Medicine, Infectious Diseases, Microbiology +12

Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

Martin A. Maier, Muthusamy Jayaraman, Shigeo Matsuda et al. · Molecular Therapy · 2013 · 619 citations · Full text

Pharmacy, Biotechnology, Pharmaceutics +17

Circular RNA vaccines against SARS-CoV-2 and emerging variants

Liang Qu, Zongyi Yi, Yong Shen et al. · Cell · 2022 · 609 citations · Full text

Veterinary Medicine, Immunology, Infectious Diseases +17

Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

Siddharth Patel, N. Ashwanikumar, Ema Robinson et al. · Nature Communications · 2020 · 558 citations · Full text

Pharmacy, Molecular Biology, Pharmaceutics +17