IL-13Rα2/TGF-<b>β</b> bispecific CAR-T cells counter TGF-<b>β</b>-mediated immune suppression and potentiate anti-tumor responses in glioblastoma - Concepedia

Concepedia

Publication | Open Access

IL-13Rα2/TGF-<b>β</b> bispecific CAR-T cells counter TGF-<b>β</b>-mediated immune suppression and potentiate anti-tumor responses in glioblastoma

DOI Full Paper Access

45

Citations

58

References

2024

Year

Andrew J. Hou, Ryan Shih, Benjamin R. Uy, Amanda Shafer, Z.L. Chang, Begonya Comin-Anduix, Miriam Güemes, Zoran Galić, Su Phyu, Hideho Okada,

Abstract

Our findings demonstrate that by reprogramming tumor-specific T-cell responses to TGF-β, bispecific IL-13Rα2/TGF-β CAR-T cells resist and remodel the immunosuppressive TME to drive potent anti-tumor responses in GBM.

References

	Year	Citations

Page 1