Enantioselective alkylation of α-amino C(sp3)−H bonds via photoredox and nickel catalysis

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

Frank Lovering, Jack Bikker, Christine Humblet · Journal of Medicinal Chemistry · 2009 · 4.2K citations

A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents

Tian Qin, Josep Cornellà, Chao Li et al. · Science · 2016 · 724 citations · Full text

Chemical Engineering, Cross-coupling Reaction, Engineering +14

Enantioselective cyanation of benzylic C–H bonds via copper-catalyzed radical relay

Wen Zhang, Fei Wang, Scott D. McCann et al. · Science · 2016 · 661 citations · Full text

Selective sp3 C–H alkylation via polarity-match-based cross-coupling

Chi “Chip” Le, Yufan Liang, Ryan W. Evans et al. · Nature · 2017 · 550 citations · Full text

Cross-coupling Reaction, Organometallic Catalysis, Chemistry +1

Pd(II)-Catalyzed Enantioselective C–H Activation of Cyclopropanes

Masayuki Wasa, Keary M. Engle, David W. Lin et al. · Journal of the American Chemical Society · 2011 · 403 citations

Medicinal Chemistry, Novel Organocatalysts, Engineering +13