Resatorvid (TAK-242) Ameliorates Ulcerative Colitis by Modulating Macrophage Polarization and T Helper Cell Balance via TLR4/JAK2/STAT3 Signaling Pathway

Interleukin-13 Is the Key Effector Th2 Cytokine in Ulcerative Colitis That Affects Epithelial Tight Junctions, Apoptosis, and Cell Restitution

Frank Heller, Peter Florian, Christian Bojarski et al. · Gastroenterology · 2005 · 1.1K citations · Full text

Life Sciences, Immunology, Pathology +17

Interleukin-13 Is the Key Effector Th2 Cytokine in Ulcerative Colitis That Affects Epithelial Tight Junctions, Apoptosis, and Cell Restitution

Frank Heller, Peter Florian, Christian Bojarski et al. · Gastroenterology · 2005 · 1K citations

Life Sciences, Immunology, Pathology +17

Distinct Cytokine Patterns Identified from Multiplex Profiles of Murine DSS and TNBS-Induced Colitis

Philip Alex, Nicholas C. Zachos, Thuan T. Nguyen et al. · Inflammatory Bowel Diseases · 2008 · 749 citations · Full text

Veterinary Medicine, Immunology, Pathology +17

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

Naoko Matsunaga, Noboru Tsuchimori, Tatsumi Matsumoto et al. · Molecular Pharmacology · 2010 · 593 citations

Life Sciences, Immunology, Molecular Biology +17

Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis

Stacey N. Harbour, Craig L. Maynard, Carlene L. Zindl et al. · Proceedings of the National Academy of Sciences · 2015 · 429 citations · Full text

Veterinary Medicine, Immunology, Pathobiology +17