Concepedia

Degrasyn alleviates osteoarthritis by blocking macrophagic pyroptosis via suppressing NLRP3/GSDMD signaling pathway and protecting chondrocytes

Shujun Xie, Linqiao Wang, Congcong Lu, Hao Chen, Yi Ding, Xu Jian, Zhen Zhang, Liulong Zhu

Cellular Signalling · 2024 · 11 citations · 20 references

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20

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi, Yue Zhao, Kun Wang et al. · Nature · 2015 · 6.5K citations

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The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

S.S. Glasson, M.G. Chambers, W. B. Van Den Berg et al. · Osteoarthritis and Cartilage · 2010 · 1.7K citations · Full text

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Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis

Kun Wang, Qi Sun, Xiu Zhong et al. · Cell · 2020 · 760 citations · Full text

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Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes

Feng Zhou, Jingtian Mei, Xiuguo Han et al. · Acta Pharmaceutica Sinica B · 2019 · 408 citations · Full text

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Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis

Vaibhav Kapuria, Luke F. Peterson, Dexing Fang et al. · Cancer Research · 2010 · 395 citations

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