Concepedia

Single-shot dendritic cell targeting SARS-CoV-2 vaccine candidate induces broad, durable and protective systemic and mucosal immunity in mice

Nicholas You Zhi Cheang, Kai Sen Tan, Peck Szee Tan, Kiren Purushotorma, Wee Chee Yap, Kirsteen M. Tullett, Benson Yen Leong Chua, Aileen Ying-Yan Yeoh, Caris Qi Hui Tan, Xinlei Qian,

Molecular Therapy · 2024 · 11 citations · 47 references

DOIFull text

Open access

Concepts

Abstract

decrease in lung viral loads compared with non-immunized controls. Therefore, Clec9A-RBD immunization has the potential to trigger robust and sustained, systemic and mucosal protective immunity against rapidly evolving SARS-CoV2 variants.

References

47

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Fei Zhou, Ting Yu, Ronghui Du et al. · The Lancet · 2020 · 29.1K citations · Full text

, , +12

<i>Batf3</i> Deficiency Reveals a Critical Role for CD8α <sup>+</sup> Dendritic Cells in Cytotoxic T Cell Immunity

Kai Hildner, Brian T. Edelson, Whitney E. Purtha et al. · Science · 2008 · 2K citations

, , +17

Differential Antigen Processing by Dendritic Cell Subsets in Vivo

Diana Dudziak, Alice O. Kamphorst, Gordon F. Heidkamp et al. · Science · 2007 · 1.4K citations · Full text

, , +17

Cd8+ but Not Cd8− Dendritic Cells Cross-Prime Cytotoxic T Cells in Vivo

Joke M. M. den Haan, Sophie M. Lehar, Michael J. Bevan · The Journal of Experimental Medicine · 2000 · 1.3K citations · Full text

, , +17

mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern

Rishi R. Goel, Mark M. Painter, Sokratis A. Apostolidis et al. · Science · 2021 · 937 citations · Full text

, , +17