Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2

Neutrophil Extracellular Traps Kill Bacteria

Volker Brinkmann, Ulrike Reichard, Christian Goosmann et al. · Science · 2004 · 9.8K citations

Inflammation, Bacterial Infections, Microbial Pathogens +14

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Veit Hornung, Andrea Ablasser, Marie Charrel-Dennis et al. · Nature · 2009 · 2.5K citations · Full text

Signal Transduction, Natural Sciences, Cell Interaction +12

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Teresa Fernandes‐Alnemri, Je‐Wook Yu, Pinaki Datta et al. · Nature · 2009 · 1.8K citations · Full text

Signal Transduction, Cell Regulation, Cell Interaction +6

Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance

Meng Zhao, Yizhuo Wang, Ling Li et al. · Theranostics · 2020 · 724 citations · Full text

AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence

SangJoon Lee, Rajendra Karki, Yaqiu Wang et al. · Nature · 2021 · 653 citations · Full text

Protein Function, Signal Transduction, Signaling Pathway +8