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A homing rescue gene drive with multiplexed gRNAs reaches high frequency in cage populations but generates functional resistance

Multiplexed GrnasNatural SciencesGeneticsGenetic EngineeringMolecular BiologyGenetic MechanismGene CharacterizationMolecular GeneticsGenomicsCage PopulationsGene ExpressionMedicineFunctional GenomicsGenome EditingFunctional ResistanceGene Transfer