A homing rescue gene drive with multiplexed gRNAs reaches high frequency in cage populations but generates functional resistance

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Life Sciences, Biochemistry, Bioinformatics +11

SignalP 6.0 predicts all five types of signal peptides using protein language models

Nature Biotechnology · 2022 · 2.8K citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +17

SignalP 6.0 predicts all five types of signal peptides using protein language models

Felix Teufel, José Juan Almagro Armenteros, Alexander Rosenberg Johansen et al. · Repository for Publications and Research Data (ETH Zurich) · 2022 · 2.1K citations · Full text

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A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes

Kyros Kyrou, Andrew Hammond, Roberto Galizi et al. · Nature Biotechnology · 2018 · 960 citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito

Andrew Hammond, Kyros Kyrou, Marco Bruttini et al. · PLoS Genetics · 2017 · 346 citations · Full text

Life Sciences, Biotechnology, Genetics +16