Biological properties of pyrroloquinoline and pyrroloisoquinoline derivatives

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.4K citations · Full text

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Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

Monroe E. Wall, Mansukh C. Wani, Clarence Cook et al. · Journal of the American Chemical Society · 1966 · 2.2K citations

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Richard Pazdur, Lawrence R. Coia, William J. Hoskins et al. · 2007 · 359 citations

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Luotonin A. A Naturally Occurring Human DNA Topoisomerase I Poison

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Preliminary pharmacologic and clinical evaluation of camptothecin sodium (NSC-100880).

Gottlieb Ja, Guarino Am, Call Jb et al. · PubMed · 1970 · 250 citations

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