Glioblastoma-Infiltrating <i>CD8</i> + T Cells Are Predominantly a Clonally Expanded <i>GZMK</i> + Effector Population

Abstract

To understand the limited efficacy of immune-checkpoint blockade in GBM, we applied a multiomics approach to understand the TIL landscape. By highlighting the enrichment of GZMK+ effector T cells and the lack of exhausted T cells, we provide a new potential mechanism of resistance to immunotherapy in GBM. This article is featured in Selected Articles from This Issue, p. 897.