Hypoxic glioblastoma-cell-derived extracellular vesicles impair cGAS-STING activity in macrophages

Abstract

Our findings suggest a mechanism by which immunosuppressive consequences of hypoxia mediated via miRNA-25/93 can be exported from hypoxic GBM cells to normoxic macrophages via EVs, thereby contributing to more widespread T-cell mediated immunosuppression in the tumor microenvironment.