Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer - Concepedia

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Methylation of GPRC5A promotes liver metastasis and docetaxel resistance through activating mTOR signaling pathway in triple negative breast cancer

DOI Full Paper Access

139

Citations

39

References

2024

Year

Xueqi Ou, Yeru Tan, Jindong Xie, Jingping Yuan, Xinpei Deng, Ruonan Shao, Cailu Song, Xi Cao, Xiaoming Xie, Rongfang He,

Drug Resistance Updates

Abstract

METTL3/YTHDF1 axis up-regulates GPRC5A expression by m6A methylation. GPRC5A activates mTORC1/p70s6k signaling pathway by recruiting mTORC1 to lysosomes, consequently promotes docetaxel-resistance and liver metastasis.

References

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