Oxidative stress suppresses <scp>PHB2</scp>‐mediated mitophagy in β‐cells <i>via</i> the Nrf2/<scp>PHB2</scp> pathway

Abstract

Our study suggested that PHB2-mediated mitophagy can protect β-cells from apoptosis via the Nrf2/PHB2 pathway under oxidative stress. Antioxidants may protect β-cell from oxidative stress by prompting PHB2-mediated mitophagy. PHB2-mediated mitophagy as a potential mechanism takes part in the oxidative stress induced β-cell injury.