Concepedia

Icaritin with autophagy/mitophagy inhibitors synergistically enhances anticancer efficacy and apoptotic effects through PINK1/Parkin-mediated mitophagy in hepatocellular carcinoma

Piao Luo, Yehai An, Jingqian He, Xuefeng Xing, Qian Zhang, Xueying Liu, Yu Chen, Haitao Yuan, Junhui Chen, Yin‐Kwan Wong,

Cancer Letters · 2024 · 73 citations · 40 references

DOI

Concepts

References

40

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

Derek P. Narendra, Seok Min Jin, Atsushi Tanaka et al. · PLoS Biology · 2010 · 2.9K citations · Full text

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The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

Michael Lazarou, Danielle A. Sliter, Lesley A. Kane et al. · Nature · 2015 · 2.7K citations

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Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

Mario Mauthe, Idil Orhon, Cecilia Rocchi et al. · Autophagy · 2018 · 2.1K citations · Full text

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Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

Kurt Degenhardt, Robin Mathew, Brian Beaudoin et al. · Cancer Cell · 2006 · 2K citations · Full text

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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

Noriyuki Matsuda, Shigeto Sato, Kahori Shiba et al. · The Journal of Cell Biology · 2010 · 1.9K citations · Full text

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