Concepedia

Nitisinone attenuates cartilage degeneration and subchondral osteoclastogenesis in osteoarthritis and concomitantly inhibits the cGAS/STING/NF-κB pathway

T. Yang, Haiwei Ma, Hehuan Lai, Yahong Lu, Kainan Ni, Xingyu Hu, Yang Zhou, Zhiguo Zhou, Weiqing Li, Jiawei Fang,

European Journal of Pharmacology · 2024 · 12 citations · 25 references

DOI

Concepts

References

25

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

Hongxu Xian, Kosuke Watari, Elsa Sánchez‐López et al. · Immunity · 2022 · 755 citations · Full text

, , +16

TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections

Seoyun Yum, Minghao Li, Yan Fang et al. · Proceedings of the National Academy of Sciences · 2021 · 538 citations · Full text

, , +17

The Prevalence of Symptomatic Knee Osteoarthritis in China: Results From the China Health and Retirement Longitudinal Study

Xu Tang, Shengfeng Wang, Siyan Zhan et al. · Arthritis & Rheumatology · 2015 · 530 citations

, , +10

Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain

Shouan Zhu, Jianxi Zhu, Gehua Zhen et al. · Journal of Clinical Investigation · 2018 · 451 citations · Full text

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LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis

Manoj Arra, Gaurav Swarnkar, Ke Ke et al. · Nature Communications · 2020 · 394 citations · Full text

, , +17