Pathogenic, Total Loss-of-Function <i>DYRK1B</i> Variants Cause Monogenic Obesity Associated With Type 2 Diabetes

Abstract

P/LP, total loss-of-function DYRK1B variants cause monogenic obesity associated with type 2 diabetes. This study underscores the significance of conducting functional assessments in order to accurately ascertain the tangible effects of P/LP DYRK1B variants.