Melatonin protects against myocardial ischemia-reperfusion injury by inhibiting excessive mitophagy through the Apelin/SIRT3 signaling axis

SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin

Huifeng Pi, Shangcheng Xu, Rüssel J. Reiter et al. · Autophagy · 2015 · 351 citations · Full text

Mitophagy, Apoptosis, Immunology +18

<i>SIRT3</i> interacts with the <i>daf-16</i> homolog <i>FOXO3a</i> in the Mitochondria, as well as increases <i>FOXO3a</i> Dependent Gene expression

Kristi Muldoon Jacobs, J. Daniel Pennington, Kheem S. Bisht et al. · International Journal of Biological Sciences · 2008 · 271 citations · Full text

Loss of Apelin Exacerbates Myocardial Infarction Adverse Remodeling and Ischemia‐reperfusion Injury: Therapeutic Potential of Synthetic Apelin Analogues

Wang Wang, Shaun M. K. McKinnie, Vaibhav B. Patel et al. · Journal of the American Heart Association · 2013 · 205 citations · Full text

Melatonin effects on myocardial ischemia–reperfusion injury: Impact on the outcome in patients undergoing coronary artery bypass grafting surgery

Karar H. Dwaich, Fadhil G. Al-Amran, Bassim I. Mohammad AL-Sheibani et al. · International Journal of Cardiology · 2016 · 113 citations

Cardiovascular Disease, Myocardial Ischemia–reperfusion Injury, Reperfusion Injury +5

Apelin gene therapy increases myocardial vascular density and ameliorates diabetic cardiomyopathy via upregulation of sirtuin 3

Heng Zeng, Xiaochen He, Xuwei Hou et al. · American Journal of Physiology-Heart and Circulatory Physiology · 2013 · 111 citations · Full text

Heart Failure, Apelin Gene Therapy, Cardiovascular Pharmacology +18