Treatment Failure in a UK Malaria Patient Harboring Genetically Variant <i>Plasmodium falciparum</i> From Uganda With Reduced In Vitro Susceptibility to Artemisinin and Lumefantrine

Abstract

We confirm, in a documented case of artemether-lumefantrine treatment failure imported from Uganda, the presence of pfk13 mutations encoding L145V and A675V. Parasites with reduced susceptibility to both artemisinin and lumefantrine may be emerging in Uganda.