MDSCs-derived GPR84 induces CD8⁺ T-cell senescence via p53 activation to suppress the antitumor response

Abstract

These data demonstrated that the transfer of GPR84 from MDSCs to CD8⁺ T cells induces T-cell senescence via the p53 signaling pathway, which could explain the strong immunosuppression of GPR84 endowed to MDSCs.