Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

Laura A. Sena, Sha Li, Amit Jairaman, +9

Immunity

InflammationAutoimmune DiseaseMitochondrial FunctionT-regulatory CellImmunology +7

Circadian Clock NAD ⁺ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

Clara Bien Peek, Alison H. Affinati, Kathryn Moynihan Ramsey, +16

Science

Mitochondrial BiologyRedox BiologyOxidative StressBiosynthesisMitochondrial Oxidative Metabolism +20

Mitochondrial complex III is essential for suppressive function of regulatory T cells

Samuel E. Weinberg, Benjamin D. Singer, Elizabeth M. Steinert, +10

Nature

Suppressive FunctionSignal TransductionMitochondrial FunctionT-regulatory CellImmunology +6

Targeting SOD1 reduces experimental non–small-cell lung cancer

Andrea Glasauer, Laura A. Sena, Lauren Diebold, +2

Journal of Clinical Investigation

A phase I trial of antibody directed enzyme prodrug therapy (ADEPT) in patients with advanced colorectal carcinoma or other CEA producing tumours

Roslyn J. Francis, Sanjay Sharma, Caroline J. Springer, +15

British Journal of Cancer

Tumour ResponseOther CeaImmunologyPathologyImmunotherapeutics +24

Tumor Frameshift Mutation Proportion Predicts Response to Immunotherapy in Mismatch Repair-Deficient Prostate Cancer

Laura A. Sena, Julia Fountain, Pedro Isaacsson Velho, +17

The Oncologist

Bipolar androgen therapy sensitizes castration-resistant prostate cancer to subsequent androgen receptor ablative therapy

Laura A. Sena, Hao Wang, Su Jin Lim, +12

European Journal of Cancer

Bipolar Androgen TherapyUrologyMedicineHormonal ReceptorCastration-resistant Prostate Cancer +3

Mitochondrial metabolism is essential for invariant natural killer T cell development and function

Xiufang Weng, Amrendra Kumar, Liang Cao, +8

Proceedings of the National Academy of Sciences

Androgen receptor activity in prostate cancer dictates efficacy of bipolar androgen therapy through MYC

Laura A. Sena, Rajendra Kumar, David E. Sanin, +22

Journal of Clinical Investigation

Androgen Receptor ActivityUrologyOncologyBipolar Androgen TherapyGenitourinary Cancer +10

Bipolar androgen therapy plus nivolumab for patients with metastatic castration-resistant prostate cancer: the COMBAT phase II trial

Mark C. Markowski, Mary‐Ellen Taplin, Rahul Aggarwal, +17

Nature Communications