Concepedia

USP28 Serves as a Key Suppressor of Mitochondrial Morphofunctional Defects and Cardiac Dysfunction in the Diabetic Heart

Saiyang Xie, Shi‐qiang Liu, Tong Zhang, Wenke Shi, Yun Xing, Wenxi Fang, Min Zhang, Meng-Ya Chen, Si‐Chi Xu, Meng-qi Fan,

Circulation · 2023 · 89 citations · 55 references

DOI

Abstract

Our findings provide a USP28-modulated mitochondria homeostasis mechanism that involves the PPARα-Mfn2 axis in diabetic hearts, suggesting that USP28 activation or adeno-associated virus therapy targeting USP28 represents a potential therapeutic strategy for diabetic cardiomyopathy.

References

55

Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition

Pouya Saeedi, Inga Petersohn, Belma Malanda et al. · Diabetes Research and Clinical Practice · 2019 · 10K citations

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Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

Linn Fagerberg, Björn M. Hallström, Per Oksvold et al. · Molecular & Cellular Proteomics · 2013 · 3.7K citations · Full text

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

Olga Martins de Brito, Luca Scorrano · Nature · 2008 · 2.3K citations

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New type of cardiomyopathy associated with diabetic glomerulosclerosis

Shirley Rubler, Joel Dlugash, Yusuf Ziya Yuceoglu et al. · The American Journal of Cardiology · 1972 · 1.8K citations

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PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

Yun Chen, Gerald W. Dorn · Science · 2013 · 1.3K citations

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