Alleviation of DSS-induced colitis via bovine colostrum-derived extracellular vesicles with microRNA <i>let-7a-5p</i> is mediated by regulating <i>Akkermansia</i> and <b>β</b> -hydroxybutyrate in gut environments

Abstract

Even though studying on the possible involvement of extracellular vesicles (EVs) in host-microbe interactions, how these relationships mediate host physiology has not clarified yet. Our current findings provide insights into the encouraging benefits of dietary source-derived EVs and microRNAs (miRNAs) on organic acid production and ultimately stimulating gut microbiome for human health, suggesting that supplementation of dietary colostrum EVs and miRNAs is a novel preventive strategy for the treatment of inflammatory bowel disease.