Crystalline silica-induced proinflammatory eicosanoid storm in novel alveolar macrophage model quelled by docosahexaenoic acid supplementation

Abstract

FLAMs are amenable to lipidome modulation by DHA which suppresses cSiO₂-triggered production of ARA-derived eicosanoids and proinflammatory cytokines. FLAMs are a potential <i>in vitro</i> alternative to primary AMs for investigating interventions against early toxicant-triggered inflammation in the lung.