Effects of gene polymorphisms on delayed MTX clearance, toxicity, and metabolomic changes after HD-MTX treatment in children with acute lymphoblastic leukemia

The 1298A→C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine

Inbal Weisberg · Atherosclerosis · 2001 · 367 citations

Life Sciences, Genetics, Molecular Genetics +9

The lncRNA-GAS5/miR-221-3p/DKK2 Axis Modulates ABCB1-Mediated Adriamycin Resistance of Breast Cancer via the Wnt/β-Catenin Signaling Pathway

Zhaolin Chen, Tingting Pan, Duochen Jiang et al. · Molecular Therapy — Nucleic Acids · 2020 · 139 citations · Full text

Medicine, Cancer Biology, Oncology +17

Genetic polymorphisms associated with adverse events and elimination of methotrexate in childhood acute lymphoblastic leukemia and malignant lymphoma

Hiroyuki Imanishi, Noboru Okamura, Mariko Yagi et al. · Journal of Human Genetics · 2006 · 116 citations

Medicine, Genetics, Pediatrics +17

Validity and Reliability of the Pediatric Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events

Bryce B. Reeve, Molly McFatrich, Jennifer W. Mack et al. · JNCI Journal of the National Cancer Institute · 2020 · 98 citations · Full text

Medicine, Oncology, Pediatrics +16

Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition

D. Sean Froese, J. Kopec, Elzbieta Rembeza et al. · Nature Communications · 2018 · 86 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13