Concepedia

Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity

Chunyuan Zhao, Yunjin Ma, Minghui Zhang, Xiaoyan Gao, Wenbo Liang, Ying Qin, Yue Fu, Mutian Jia, Hui Song, Chengjiang Gao,

Immunity · 2023 · 64 citations · 32 references

DOI

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32

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

Mingjian Du, Zhijian J. Chen · Science · 2018 · 1K citations · Full text

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Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC).

Michael J. Behe, Gary Felsenfeld · Proceedings of the National Academy of Sciences · 1981 · 887 citations · Full text

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Structural mechanism of cytosolic DNA sensing by cGAS

Filiz Çivril, Tobias Deimling, Carina C. de Oliveira Mann et al. · Nature · 2013 · 871 citations · Full text

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Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses

Chenguang Wang, Yukun Guan, Mengze Lv et al. · Immunity · 2018 · 814 citations · Full text

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Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis

Ting Zhang, Chaoran Yin, David F. Boyd et al. · Cell · 2020 · 557 citations · Full text

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