Piezo1 transforms mechanical stress into pro senescence signals and promotes osteoarthritis severity

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

Bertrand Coste, Jayanti Mathur, Manuela Schmidt et al. · Science · 2010 · 3.2K citations · Full text

Life Sciences, Cell Biology, Neuroscience +17

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

Ok Hee Jeon, Chaekyu Kim, Remi-Martin Laberge et al. · Nature Medicine · 2017 · 1.5K citations · Full text

Dentistry, Cell Biology, Orthopaedic Surgery +17

Piezo1 integration of vascular architecture with physiological force

Jing Li, Bing Hou, Sarka Tumova et al. · Nature · 2014 · 1.2K citations

Engineering, Bioengineering, Biomedical Engineering +15

Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition

Branca Pereira, Oliver Devine, Milica Vukmanovic‐Stejic et al. · Nature Communications · 2019 · 533 citations · Full text

Life Sciences, Cell Biology, Immunology +16

Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage

Whasil Lee, Holly A. Leddy, Yong Chen et al. · Proceedings of the National Academy of Sciences · 2014 · 462 citations · Full text

Natural Sciences, Biophysics, Physiology +17