Concepedia

Control of the antitumour activity and specificity of CAR T cells via organic adapters covalently tethering the CAR to tumour cells

Jia Xie, Qiaoqiao Zhu, Zuyuan Shen, Wenji Su, Letian Kuai, Richard Söll, Christoph Rader, Geramie Shaver, Lacey Douthit, Ding Zhang,

Nature Biomedical Engineering · 2023 · 25 citations · 70 references

Concepts

Life SciencesImmunologyOncologyCancer ImmunologyImmunotherapyTumor ImmunologyAntitumor T Cell ResponsesCancer ImmunotherapyCytotoxic T Lymphocyte ResponsesLigand-mediated TargetingT Cell Activation ControlT Cell BiologyT Cell CytotoxicityT Cell Receptor-engineered T CellsT Cell-mediated Tumor KillingT-cell Receptor-engineered T CellsT-cell Responses To Tumor AntigensT-cell Therapy

References

70

Cancer statistics, 2022

Rebecca L. Siegel, Kimberly D. Miller, Hannah E. Fuchs et al. · CA A Cancer Journal for Clinicians · 2022 · 18.2K citations · Full text

Medicine, Oncology, Cancer Epidemiology +16

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

Sattva S. Neelapu, Frederick L. Locke, Nancy L. Bartlett et al. · New England Journal of Medicine · 2017 · 5.9K citations · Full text

Medicine, Hematology, Oncology +16

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

Shannon L. Maude, Theodore W. Laetsch, Jochen Buechner et al. · New England Journal of Medicine · 2018 · 5.6K citations · Full text

Medicine, Hematology, Oncology +17

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

Daniel W Lee, James N. Kochenderfer, Maryalice Stetler‐Stevenson et al. · The Lancet · 2014 · 2.9K citations

Life Sciences, Hematology, Oncology +17

Inducible Apoptosis as a Safety Switch for Adoptive Cell Therapy

Antonio Di Stasi, Siok‐Keen Tey, Gianpietro Dotti et al. · New England Journal of Medicine · 2011 · 1.5K citations · Full text

Life Sciences, Biotechnology, Immunology +13