Genome‐wide screening for selection signatures in native and cosmopolitan cattle breeds reared in Türkiye

Abstract

Abstract Via long‐term natural and artificial selection pressure, homozygosity may extend across the genome, leaving genomic patterns called selection signatures. This study is the first attempt to assess genome‐wide selection signatures in six native Turkish and two cosmopolitan cattle breeds by 211.119 bi‐allelic SNPs recovered using the double digest restriction associated DNA sequencing method. The integrated haplotype score (iHS) statistic was utilised to reveal selection signatures within populations, whereas the cross‐population extended haplotype homozygosity (XP‐EHH) and fixation index ( F ST ) approaches were preferred to reveal differently fixed genomic regions between native Turkish and cosmopolitan cattle breeds. Selection signatures in 142 genomic regions containing 305 genes were detected within eight cattle breeds by iHS statistics. The XP‐EHH and F ST approaches revealed that 197 and 114 SNPs were under selection pressure, respectively, which overlapped with 144 and 190 genes, respectively. A total of 18 genes were detected by at least two approaches. Six genes related to disease resistance ( TTP2 ), meat yield ( DIAPH3 and METTL21C ), meat quality ( ZNF24 and ZNF397 ) and first calving interval ( ZSCAN30 ) turned out to be differently fixed between native Turkish and cosmopolitan cattle breeds, as they were identified by both XP‐EHH and F ST approaches. In addition, the iHS approach revealed that eight genes associated with visual modality ( LSGN ), olfaction ( MOXD2 , OR4C1F and OR4C1F ), and immune response ( TRBV3‐1 and CLDN10 ) were under selection pressure in both native and cosmopolitan cattle breeds. Owing to their being significantly related to survival traits, these regions may have played a key role in cattle genome evolution. Future studies utilising denser genetic data are required to obtain deeper knowledge on effects of natural and artificial selection in Anatolian cattle breeds. © 2023 Stichting International Foundation for Animal Genetics.