Theranostics · 2023 · 21 citations · 40 references
PharmacyPharmaceuticsPharmacologyDrug DeliveryNanoparticle Drug DeliveryTargeted Drug DeliveryAcute Respiratory Distress SyndromeGene Delivery To The LungLipid-based NanoparticlesLung TargetingNanocarriers For TherapeuticsNanomedicineLipid Nanoparticle DeliveryLipid NanoparticlesLocalized Drug DeliveryMrna Delivery SystemsMrna Lipid NanoparticlesNanoparticle DeliveryNanoparticle Delivery VectorsProgrammed Death-ligand 1 Targeting
This study demonstrates the feasibility of utilizing stable and reliable mRNA to express the immunosuppressive molecule sPD-L1 specifically in the lungs. The findings provide proof of concept for localized nanoparticle delivery and offer a novel therapeutic strategy for treating acute inflammation in ARDS.
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