Concepedia

Green and rapid acid-catalyzed ynamide skeletal rearrangement and stereospecific functionalization with anisole derivatives

Mohana Reddy Mutra, T. L. Chandana, Yun-Jou Wang, Jeh‐Jeng Wang

Green Chemistry · 2023 · 11 citations · 38 references

DOI

Concepts

Abstract

Environmentally friendly acid-catalyzed 2-alkynyl-ynamides (N–Csp) bond cleavage, alkyne migration and stereospecific functionalization with anisole derivatives for the synthesis of challenging indole scaffolds in 5–10 minutes.

References

38

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo

Jun Yan, Jie Chen, Shun Zhang et al. · Journal of Medicinal Chemistry · 2016 · 163 citations · Full text

, , +16

Exploiting Remarkable Reactivities of Ynamides: Opportunities in Designing Catalytic Enantioselective Reactions

Jian Luo, Guo‐Shu Chen, Shujie Chen et al. · ACS Catalysis · 2020 · 159 citations

, , +17

Asymmetric dearomatization catalysed by chiral Brønsted acids via activation of ynamides

Yingqi Zhang, Yang‐Bo Chen, Ji‐Ren Liu et al. · Nature Chemistry · 2021 · 133 citations

, , +8

Alkoxyboration: Ring-Closing Addition of B–O σ Bonds across Alkynes

Joshua J. Hirner, Darius J. Faizi, Suzanne A. Blum · Journal of the American Chemical Society · 2014 · 117 citations · Full text

, , +12

Aminoboration: Addition of B–N σ Bonds across C–C π Bonds

Eugene Chong, Suzanne A. Blum · Journal of the American Chemical Society · 2015 · 109 citations · Full text

, , +13