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Identification and quantification of (poly)phenol and methylxanthine metabolites in human cerebrospinal fluid: evidence of their ability to cross the BBB

Mélanie Le Sayec, Diogo Carregosa, Khadija Khalifa, Chiara de Lucia, Dag Aarsland, Cláudia Nunes dos Santos, Ana Rodriguez‐Mateos

Food & Function · 2023 · 21 citations · 20 references

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Abstract

We investigated the presence of (poly)phenol and methylxanthine metabolites in plasma and cerebrospinal fluid from individuals at risk of dementia suing LC-MS and predicted their mechanism of transport across the BBB using in silico modelling.

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