C1q⁺ tumor-associated macrophages contribute to immunosuppression through fatty acid metabolic reprogramming in malignant pleural effusion

Abstract

C1q⁺ TAMs impede antitumor effects of CD8⁺ T cells promoting MPE immunosuppression. Targeting C1q⁺ TAMs effectively alleviates the immunosuppression and enhances the efficacy of ICB therapy. C1q⁺ TAMs subset has great potential to be a therapeutic target for cancer immunotherapy.