Concepedia

Autophagy induced by PP121 alleviates MSU crystal-induced acute gouty arthritis via inhibition of the NLRP3 inflammasome

Wei Yuan, Teng Liu, Yuanyi Wang, Shuang He, Feng Zhang, Xiao-bian Wang, Shihua Deng, Ting Zhang, Dong-ming Wu, Ying Xu

International Immunopharmacology · 2023 · 13 citations · 24 references

DOI

Concepts

References

24

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

The EMBO Journal · 2000 · 6.5K citations · Full text

, , +11

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi, Yue Zhao, Kun Wang et al. · Nature · 2015 · 6.5K citations

, , +14

Gout-associated uric acid crystals activate the NALP3 inflammasome

Fabio Martinon, Virginie Pétrilli, Annick Mayor et al. · Nature · 2006 · 5.2K citations

, , +11

2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia

Dinesh Khanna, John FitzGerald, Puja Khanna et al. · Arthritis Care & Research · 2012 · 1.5K citations · Full text

, , +13

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

Beth Apsel, Jimmy A. Blair, Beatriz González et al. · Nature Chemical Biology · 2008 · 439 citations · Full text

, , +14