Concepedia

Disease-modifying interactions between chronic kidney disease and osteoarthritis: a new comorbid mouse model

Sohel M. Julovi, Aiken Dao, Katie Trinh, Alexandra K O’Donohue, Cindy C. Shu, Susan M. Smith, Meena Shingde, Aaron Schindeler, Natasha M. Rogers, Christopher B. Little

RMD Open · 2023 · 17 citations · 33 references

DOIFull text

Open access

Abstract

This study assessed a world-first preclinical comorbid CKD-OA model. Our findings demonstrate significant bidirectional disease-modifying interaction between CKD and OA.

References

33

Definition, evaluation, and classification of renal osteodystrophy: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)

Sharon M. Moe, Tilman B. Drüeke, John Cunningham et al. · Kidney International · 2006 · 1.9K citations

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Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

Gehua Zhen, Chunyi Wen, Xiaofeng Jia et al. · Nature Medicine · 2013 · 922 citations · Full text

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Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

Christopher B. Little, Amlan Barai, Dan Burkhardt et al. · Arthritis & Rheumatism · 2009 · 615 citations · Full text

Evidence for increased bone resorption in patients with progressive knee osteoarthritis: Longitudinal results from the Chingford study

P. Bettica, Gary A. Cline, Deborah Hart et al. · Arthritis & Rheumatism · 2002 · 296 citations

Inhibition of interleukin‐1β‐stimulated production of matrix metalloproteinases by hyaluronan via CD44 in human articular cartilage

Sohel M. Julovi, Tadashi Yasuda, Makoto Shimizu et al. · Arthritis & Rheumatism · 2004 · 157 citations · Full text