Concepedia

Publication | Open Access

Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity

DOIFull Paper Access

10

Citations

16

References

2023

Year

Moon Hee Yang, Timothy H. Tran, Bethany Hunt, Rebecca Agnor, Christian W. Johnson, Bing Shui, Timothy J. Waybright, Jonathan A. Nowak, Andrew G. Stephen, Dhirendra K. Simanshu,
Cancer Research

Abstract

An allosteric network formed by interaction between lysine 104 and residues in the switch-II domain is required for KRAS oncogenicity, which could be exploited for developing inhibitors of the activated oncoprotein.

References

YearCitations

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